Addition of Rosiglitazone to Glimepirid and Metformin Combination Therapy in Type 2 Diabetes

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Addition of incretin therapy to metformin in type 2 diabetes.

Incretin-based therapies offer a new approach for the management of type 2 diabetes, with a mechanism of action distinct from any existing class of glucose-lowering agents. These drugs improve the body's ability to control blood glucose by increasing active concentrations of glucagon-like peptide-1 (GLP-1). Two approaches have been used to enhance the action of GLP-1. First, incretin mimetics (...

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Comparison of metformin, gliclazide MR and rosiglitazone in monotherapy and in combination for type 2 diabetes.

OBJECTIVE To compare the efficacy and tolerability of metformin, rosiglitazone and gliclazide MR as monotherapy and in combination in the treatment of type 2 diabetes. SUBJECTS AND METHODS 250 patients treated with oral antidiabetic agents for at least 24 weeks in monotherapy or in combination therapy were included in this retrospective study. RESULTS As monotherapy the reduction of fasting...

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ژورنال

عنوان ژورنال: Endocrine Journal

سال: 2004

ISSN: 0918-8959,1348-4540

DOI: 10.1507/endocrj.51.521